Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592276 | 0.83 | DEGS1 (0.48) | HPGDNPC1RAB9ANPSR1KMT2A | |
| SCHEMBL12892631 | 0.83 | KMT2A (0.49) | NPC1RAB9ANPSR1KMT2ADEGS1 | |
| SCHEMBL3640546 | 0.81 | MAPT (0.51) | HPGDNPC1RAB9ANPSR1KMT2A | |
| SCHEMBL14742481 | 0.81 | DEGS1 (0.47) | HPGDNPC1RAB9ANPSR1KMT2A | |
| SCHEMBL4399389 | 0.79 | NPC1 (0.46) | HPGDNPC1RAB9ANPSR1KMT2A | |
| SCHEMBL11485382 | 0.77 | RAB9A (0.59) | HPGDNPC1RAB9AKMT2ALMNA | |
| SCHEMBL12917668 | 0.77 | MAPT (0.43) | NPC1RAB9ANPSR1KMT2ADEGS1 | |
| SCHEMBL31398615 | 0.76 | MAPK1 (0.53) | NPC1RAB9AKMT2ADEGS1LMNA | |
| SCHEMBL14267861 | 0.76 | APP (0.53) | NPC1RAB9AKMT2ADEGS1MAPT | |
| SCHEMBL6844995 | 0.76 | MAPT (0.49) | HPGDNPC1RAB9AKMT2ADEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136663-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | WO | disclosed |