Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354851 | 0.92 | USP30 (0.44) | USP30NPY1RPIM1PIM3PIM2 | |
| SCHEMBL13623217 | 0.86 | HTR1A (0.42) | NPY1RTLR7CYP3A4CYP2C19HTR1A | |
| SCHEMBL13623214 | 0.85 | AKT1 (0.49) | NPY1RTLR7CYP3A4CYP2C19AKT1 | |
| SCHEMBL1083487 | 0.82 | TLR7 (0.37) | USP30NPY1RTLR7CYP3A4CYP2C19 | |
| SCHEMBL1083486 | 0.82 | TLR7 (0.37) | USP30NPY1RTLR7CYP3A4CYP2C19 | |
| SCHEMBL13622510 | 0.78 | AURKA (0.43) | NPY1RTLR7CYP3A4CYP2C19AURKA | |
| SCHEMBL13670174 | 0.78 | AURKA (0.43) | NPY1RTLR7CYP3A4CYP2C19AURKA | |
| SCHEMBL4365340 | 0.76 | JAK3 (0.39) | USP30NPY1RHTR1AHTR1DHTR1B | |
| SCHEMBL13622713 | 0.76 | AURKA (0.48) | NPY1RTLR7CYP3A4CYP2C19AURKA | |
| SCHEMBL13669878 | 0.76 | NOX4 (0.45) | TLR7CYP3A4CYP2C19AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | USP30 1344/4885NPY1R 3180/4885PIM1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.