Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1175359 | 0.85 | TTR (0.45) | SHBGTTRALBMEN1KMT2A | |
| SCHEMBL13623355 | 0.81 | TTR (0.42) | TTRALBMEN1KMT2AHTT | |
| SCHEMBL197918 | 0.81 | TTR (0.58) | TTRALBMEN1KMT2ALMNA | |
| SCHEMBL4521834 | 0.81 | TTR (0.36) | SHBGTTRALBMEN1KMT2A | |
| SCHEMBL12002282 | 0.79 | TTR (0.44) | SHBGTTRALBMEN1KMT2A | |
| SCHEMBL6516703 | 0.76 | EGFR (0.39) | SHBGTTRALBMEN1KMT2A | |
| SCHEMBL27755117 | 0.75 | TTR (0.52) | TTRALBMEN1KMT2ALMNA | |
| SCHEMBL18300739 | 0.75 | TTR (0.41) | TTRALBMEN1KMT2AKDM4E | |
| SCHEMBL8436238 | 0.74 | CYP2A6 (0.41) | SHBGMEN1KMT2ACA2ALDH1A1 | |
| SCHEMBL410177 | 0.74 | CYP2A6 (0.41) | MEN1KMT2ACA2ALDH1A1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | RHODES GERALD | 2009-11-26 | — | — | US | disclosed |
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | RHODES GERALD | 2009-11-26 | — | — | US | disclosed |
| US-7585884-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585884-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | VIROPHARMA INCORPORATED | 2008-11-27 | — | — | US | disclosed |
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | VIROPHARMA INCORPORATED | 2008-11-27 | — | — | US | disclosed |
| US-7429606-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429606-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | PLEC, CPSF7, CPSF1 | SHBG 4451/4885TTR 161/4885ALB 1009/4885 |
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | PLEC, CPSF7, CPSF1 | SHBG 4451/4885TTR 161/4885ALB 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.