PLEC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL440145	0.52	2/20
SCHEMBL267036	0.48	2/20
SCHEMBL273459	0.48	2/20
SCHEMBL598371	0.45	2/20
Rhein (SCHEMBL25253)	1.00	1/20
SCHEMBL109854	1.00	1/20
SCHEMBL265592	1.00	1/20
SCHEMBL700390	1.00	1/20
SCHEMBL940682	1.00	1/20
Rhein (SCHEMBL526035)	0.97	1/20
SCHEMBL430100	0.91	1/20
SCHEMBL183540	0.80	1/20
SCHEMBL183687	0.80	1/20
SCHEMBL525302	0.77	1/20
SCHEMBL1032816	0.77	1/20
Quinizarin (SCHEMBL160038)	0.76	1/20
SCHEMBL525762	0.76	1/20
SCHEMBL420071	0.76	1/20
SCHEMBL420210	0.76	1/20
SCHEMBL670696	0.75	1/20

Clinical trials — most relevant to PLEC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer	PHASE2	COMPLETED
Trial to Investigate Intensified Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer	PHASE2	COMPLETED
Quantitating the Impact of Plerixafor	PHASE1/PHASE2	UNKNOWN
Phase II Dasatinib Study in Advanced Breast Cancer	PHASE2	COMPLETED
Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors	PHASE1	COMPLETED
Interventional Therapy Sequential With the Fourth-generation CAR-T Targeting Nectin4/FAP for Malignant Solid Tumors	PHASE1	UNKNOWN
Detection of Pleural Effusion by Internal Thoracic Impedance Method	nan	UNKNOWN
Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients	nan	RECRUITING
Optimal Number of Pleural Biopsies During Pleuroscopy	nan	COMPLETED
Using Pleural Effusions to Diagnose Cancer	nan	COMPLETED
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRA	nan	RECRUITING
Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers	nan	RECRUITING
Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions	nan	RECRUITING
Circular RNA and Chemerin in Breast Cancer Patient	nan	UNKNOWN
Evaluation of a New Approach of the Diagnosis of Constitutional Functional Disorders of Platelets	nan	COMPLETED
A Comprehensive Evaluation of Circulating Tumor DNA and Circulating Tumor Cells as a Predictive Marker in Lung Cancer	nan	COMPLETED
Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis	nan	COMPLETED
Clinical Application of PET Imaging Targeting MSLN in Malignant Tumors	nan	RECRUITING
Genetic and Protein Profiling in Normal and Cancerous Breast Tissue	nan	COMPLETED
Monitoring of Breathing Effort Through Pressure Time Product Measurement Using Airway Occlusion Pressure	nan	UNKNOWN
Biomarker Breast Pap Test	nan	UNKNOWN
Detection of Biomarkers in Abnormal Cervical Cells in Women With Abnormal Pap Test Results	nan	COMPLETED
Investigation of Secreted Phosphoproteins and PiP3 (Phosphoinositolphospat 3) in Sputum	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Biomarkers to Detect Mesothelioma Early in Patients Exposed to Asbestos or Vermiculite	nan	COMPLETED
Biomarkers of CASH	nan	ACTIVE_NOT_RECRUITING
Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes	nan	COMPLETED
The Assessment of Mesothelin Antigen Specific Immunologic Assays in Ovarian Cancer Patients	nan	UNKNOWN
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)	nan	UNKNOWN
Prognostic Markers of Gynecologic Cancers	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PLEC binder may also engage these)

Protein	Name	Similarity
Q9QXS1	—	1.000	Q9QXS1 →
P30427	—	1.000	P30427 →
Q9JI55	—	0.996	Q9JI55 →
Q9QXZ0	—	0.990	Q9QXZ0 →
D3ZHV2	—	0.989	D3ZHV2 →
MACF1	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	0.989	landscape →
A2CG49	—	0.989	A2CG49 →
P11533	—	0.987	P11533 →
O60437	—	0.987	O60437 →
P11532	—	0.987	P11532 →
Q0KL02	—	0.987	Q0KL02 →
G3V7L1	—	0.987	G3V7L1 →
Q5GN48	—	0.987	Q5GN48 →
Q9D952	—	0.987	Q9D952 →
P97924	—	0.986	P97924 →
O97592	—	0.986	O97592 →
Q6ZWR6	—	0.986	Q6ZWR6 →
O60229	—	0.986	O60229 →
O75962	—	0.986	O75962 →
Q1LUA6	—	0.986	Q1LUA6 →
Q03001	—	0.985	Q03001 →
Q91ZU6	—	0.985	Q91ZU6 →
Q9R269	—	0.985	Q9R269 →
Q9Y103	—	0.985	Q9Y103 →
Q8NF91	—	0.984	Q8NF91 →
Q9NRC6	—	0.984	Q9NRC6 →
F1M0Z1	—	0.984	F1M0Z1 →
Q8K2H4	—	0.984	Q8K2H4 →
O15068	—	0.983	O15068 →
Q9VDW6	—	0.983	Q9VDW6 →