Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623365 | 0.91 | NR1I2 (0.44) | NR1I2CYP3A4CYP2D6ALDH1A1ERN1 | |
| SCHEMBL13623368 | 0.79 | NR1I2 (0.47) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL8874878 | 0.78 | NR1I2 (0.46) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL13623369 | 0.76 | NR1I2 (0.44) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL13688008 | 0.76 | NR1I2 (0.52) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL9863105 | 0.76 | CYP2D6 (0.50) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL9178754 | 0.74 | CYP2D6 (0.57) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL8875268 | 0.73 | CYP2D6 (0.56) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL9201165 | 0.73 | CYP2D6 (0.56) | NR1I2CYP3A4CYP2D6ALDH1A1MEN1 | |
| SCHEMBL13623353 | 0.73 | NR1I2 (0.71) | NR1I2CYP3A4CYP2D6HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | RHODES GERALD | 2009-11-26 | — | — | US | disclosed |
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | RHODES GERALD | 2009-11-26 | — | — | US | disclosed |
| US-7585884-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585884-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | VIROPHARMA INCORPORATED | 2008-11-27 | — | — | US | disclosed |
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | VIROPHARMA INCORPORATED | 2008-11-27 | — | — | US | disclosed |
| US-7429606-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429606-B2 | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents | VIROPHARMA INCORPORATED (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293783-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | PLEC, CPSF7, CPSF1 | NR1I2 1884/4885CYP3A4 771/4885CYP2D6 2441/4885 |
| US-20090291990-A1 | OXADIAZOLYL-PHENOXYALKYLISOXAZOLES, COMPOSITIONS THEREOF AND METHODS FOR THEIR USE AS ANTI-PICORNAVIRAL AGENTS | PLEC, CPSF7, CPSF1 | NR1I2 1884/4885CYP3A4 771/4885CYP2D6 2441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.