Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CCR4 | P51679 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306059 | 0.87 | CYP2C9 (0.51) | CYP2C9ALDH1A1TP53SMN1; SMN2CCR2 | |
| SCHEMBL306862 | 0.82 | CYP2C9 (0.60) | CYP2C9CCR2CYP3A4 | |
| SCHEMBL12594683 | 0.79 | CCR2 (0.49) | CYP2C9ALDH1A1TP53CCR2CYP3A4 | |
| SCHEMBL13623790 | 0.79 | CCR2 (0.39) | CYP2C9ALDH1A1TP53CCR2CYP3A4 | |
| SCHEMBL10272350 | 0.78 | CYP2C9 (0.53) | CYP2C9CCR2CYP3A4CYP2C19CCR4 | |
| SCHEMBL10272290 | 0.78 | CYP3A4 (0.63) | CYP2C9CCR2CYP3A4CYP2C19CCR4 | |
| SCHEMBL12594353 | 0.78 | MEN1 (0.50) | CYP2C9CCR2CYP3A4CYP2C19CCR4 | |
| SCHEMBL12593734 | 0.77 | CYP2C9 (0.56) | CYP2C9CCR2CYP3A4 | |
| SCHEMBL307207 | 0.76 | CYP2C9 (0.48) | CYP2C9ALDH1A1TP53CCR2CYP3A4 | |
| SCHEMBL10223328 | 0.76 | CCR2 (0.57) | CYP2C9ALDH1A1SMN1; SMN2CCR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |