Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CCR4 | P51679 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125771 | 0.85 | CYP2C9 (0.49) | CCR2CYP2C9CYP3A4 | |
| SCHEMBL125394 | 0.80 | CYP2C9 (0.59) | CCR2CYP2C9CYP3A4 | |
| SCHEMBL13623787 | 0.79 | CYP2C9 (0.41) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL10272290 | 0.75 | CYP3A4 (0.63) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL10272350 | 0.75 | CYP2C9 (0.53) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL127008 | 0.74 | CCR2 (0.61) | CCR2CYP2C9CYP3A4 | |
| SCHEMBL10272292 | 0.74 | CYP3A4 (0.41) | CCR2CYP2C9CYP3A4KMT2AALDH1A1 | |
| SCHEMBL12594906 | 0.71 | CCR2 (0.49) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL12594873 | 0.71 | CCR2 (0.45) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL12594828 | 0.70 | MEN1 (0.53) | CCR2CYP2C9CYP3A4CYP2C19CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |