Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13623929 | 1.00 | NR3C1 (0.59) | NR3C1HPGDSPHK2SPHK1MGLL | |
| SCHEMBL13623933 | 0.84 | NR3C1 (0.44) | NR3C1HPGDMGLLMAPK8MAPK10 | |
| SCHEMBL3149817 | 0.80 | NR3C1 (0.79) | NR3C1 | |
| SCHEMBL3149809 | 0.80 | NR3C1 (0.79) | NR3C1 | |
| SCHEMBL3154662 | 0.80 | NR3C1 (0.79) | NR3C1 | |
| SCHEMBL3145415 | 0.78 | NR3C1 (0.86) | NR3C1 | |
| SCHEMBL3145408 | 0.78 | NR3C1 (0.86) | NR3C1 | |
| SCHEMBL3149497 | 0.77 | NR3C1 (0.85) | NR3C1 | |
| SCHEMBL3149482 | 0.77 | NR3C1 (0.85) | NR3C1 | |
| SCHEMBL14022281 | 0.76 | NR3C1 (0.52) | NR3C1PDK2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142569-A1 | PHENYL OR PYRIDINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | WO | disclosed |