Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CCR2 | P41597 | 5/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CCR4 | P51679 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304894 | 0.94 | CCR2 (0.50) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL18707956 | 0.92 | ALDH1A1 (0.48) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL12594335 | 0.92 | CCR2 (0.57) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL14620491 | 0.89 | CCR2 (0.43) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL10222780 | 0.87 | CYP2C9 (0.57) | CCR2CYP2C9CYP3A4CYP2C19CCR4 | |
| SCHEMBL10223322 | 0.86 | CCR2 (0.59) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL29888391 | 0.86 | CCR2 (0.59) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL307457 | 0.86 | CCR2 (0.59) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL12594339 | 0.85 | CCR2 (0.48) | ALDH1A1HTTLMNACCR2CYP2C9 | |
| SCHEMBL10272266 | 0.84 | KMT2A (0.48) | ALDH1A1HTTLMNACCR2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622583-B2 | Heteroaryl sulfonamides and CCR2 | CHEMOCENTRYX, INC. (US) | 2009-11-24 | — | — | US | disclosed |