Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 6/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.42 |
| ▸ | PDE9A | O76083 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624582 | 0.83 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL16814489 | 0.81 | ALDH1A1 (0.63) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL16814492 | 0.77 | PDE9A (0.60) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL16814488 | 0.77 | KDM4E (0.52) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL16814491 | 0.77 | KDM4E (0.52) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL5323077 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL1622669 | 0.71 | PDE9A (0.62) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL1309845 | 0.69 | ERCC5 (0.54) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL18774623 | 0.69 | ERCC5 (0.56) | ALDH1A1KDM4ELMNAGAAGLA | |
| SCHEMBL11750118 | 0.68 | KDM4E (0.54) | ALDH1A1KDM4EGAAGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-7622582-B2 | Derivatives of 1-phenyl-benzofuro[3,2]pyridin-2(1H)-one | TIBOTEC BVBA (BE) | 2009-11-24 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC BVBA (BE) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213320-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | NR2C2, CYP4B1, OXER1 | ALDH1A1 1060/4885KDM4E 3819/4885LMNA 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.