Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977219 | 0.83 | ATM (0.43) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL13489760 | 0.81 | ATM (0.40) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL9977221 | 0.79 | ITGA4 (0.39) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL3198955 | 0.79 | ATM (0.41) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL9977210 | 0.79 | ITGA4 (0.40) | ATMITGA4ITGB7CTSSCTSK | |
| SCHEMBL23760082 | 0.79 | TPSAB1 (0.46) | L3MBTL1FOLH1 | |
| SCHEMBL7658205 | 0.78 | ABCB1 (0.48) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL7023492 | 0.77 | BACE1 (0.40) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL27476267 | 0.77 | BACE1 (0.40) | L3MBTL1ATMITGA4ITGB7CTSS | |
| SCHEMBL6316889 | 0.77 | ATM (0.43) | L3MBTL1ATMITGA4ITGB7CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008106080-A9 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2008106080-A2 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2008-09-04 | — | — | WO | disclosed |