Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 5/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624616 | 0.93 | ESR2 (0.44) | ESR2PTGS2PTGS1 | |
| SCHEMBL4365668 | 0.93 | ESR2 (0.46) | ESR2PTGS2PTGS1 | |
| SCHEMBL4365677 | 0.93 | ESR2 (0.46) | ESR2PTGS2PTGS1 | |
| SCHEMBL13622000 | 0.89 | ESR2 (0.46) | ESR2PTGS2PTGS1 | |
| SCHEMBL13624615 | 0.88 | ESR2 (0.47) | ESR2PTGS2PTGS1 | |
| SCHEMBL14516369 | 0.87 | ESR2 (0.58) | ESR2PTGS2 | |
| SCHEMBL13621997 | 0.87 | ESR2 (0.47) | ESR2PTGS2PTGS1 | |
| SCHEMBL13621982 | 0.87 | ESR2 (0.47) | ESR2PTGS2PTGS1 | |
| SCHEMBL14516348 | 0.86 | ESR2 (0.57) | ESR2PTGS2 | |
| SCHEMBL14516399 | 0.86 | ESR2 (0.57) | ESR2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622501-B2 | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors | MERCK FROSST CANADA & CO. (CA) | 2009-11-24 | — | — | US | disclosed |
| US-20080242643-A1 | Nitric Oxide Releasing Prodrugs of Diaryl-2-(5H)-Furanones as Cyclooxygenase-2 Inhibitors | DUFRESNE CLAUDE | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242643-A1 | Nitric Oxide Releasing Prodrugs of Diaryl-2-(5H)-Furanones as Cyclooxygenase-2 Inhibitors | PTGIS, PTGS1, PTGS2 | ESR2 1536/4885PTGS2 3/4885PTGS1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.