Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653613 | 0.89 | HRH1 (0.63) | HRH1HRH3KCNH2TACR2TACR1 | |
| SCHEMBL15569007 | 0.89 | HRH1 (0.55) | HRH1HTR2BHRH3KCNH2DRD3 | |
| SCHEMBL18884525 | 0.87 | HRH1 (0.68) | HRH1KCNH2TACR2TACR1USP2 | |
| Bilastine SCHEMBL991810 | 0.85 | HRH1 (0.82) | HRH1KCNH2USP2POLB | |
| Bilastine SCHEMBL29402994 | 0.85 | HRH1 (0.82) | HRH1KCNH2USP2POLB | |
| Bilastine SCHEMBL21815518 | 0.83 | HRH1 (0.77) | HRH1KCNH2 | |
| SCHEMBL993093 | 0.80 | HTR2B (0.55) | HRH1HTR2BKCNH2TACR2PARP1 | |
| SCHEMBL3793927 | 0.77 | HRH1 (0.79) | HRH1KCNH2TACR2TACR1 | |
| SCHEMBL991771 | 0.77 | HRH1 (0.79) | HRH1KCNH2 | |
| SCHEMBL30307024 | 0.77 | HRH1 (0.79) | HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612095-B2 | Polymorphic forms 2 and 3 of bilastin is transformed into polymorph 1, which is very stable and is not transformed into any of the other polymorphs 2 and 3; allergic reactions, pathological processes mediated by histamine | FAES FARMA, S.A. (ES) | 2009-11-03 | — | — | US | disclosed |