Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.45 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624817 | 0.89 | HRH1 (0.58) | HRH1HRH3USP2POLBKCNH2 | |
| SCHEMBL4653613 | 0.86 | HRH1 (0.63) | HRH1HRH3USP2POLBKCNH2 | |
| SCHEMBL18884525 | 0.84 | HRH1 (0.68) | HRH1USP2POLBKCNH2TACR2 | |
| Bilastine SCHEMBL29402994 | 0.82 | HRH1 (0.82) | HRH1USP2POLBKCNH2 | |
| Bilastine SCHEMBL991810 | 0.82 | HRH1 (0.82) | HRH1USP2POLBKCNH2 | |
| Bilastine SCHEMBL21815518 | 0.80 | HRH1 (0.77) | HRH1KCNH2LMNA | |
| SCHEMBL993093 | 0.77 | HTR2B (0.55) | HRH1POLBKCNH2TACR2HTR2B | |
| SCHEMBL11977258 | 0.75 | HRH1 (0.72) | HRH1KCNH2LMNACNR1APEX1 | |
| SCHEMBL991771 | 0.74 | HRH1 (0.79) | HRH1KCNH2 | |
| SCHEMBL3793927 | 0.74 | HRH1 (0.79) | HRH1KCNH2TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014026657-A2 | A PROCESS FOR THE PREPARATION OF A DERIVATIVE OF 2-METHYL-2'-PHENYLPROPIONIC ACID USING NEW INTERMEDIATES | ZENTIVA, K.S (CZ) | 2014-02-20 | — | — | WO | claimed |