Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17120436 | 0.90 | CREBBP (0.40) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL15436348 | 0.89 | HSD11B1 (0.43) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL15436370 | 0.88 | HSD11B1 (0.46) | HSD11B1CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15241501 | 0.84 | CREBBP (0.42) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL17120419 | 0.83 | HSD11B1 (0.48) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL14865086 | 0.83 | CREBBP (0.40) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL15436415 | 0.83 | CREBBP (0.40) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL17120435 | 0.83 | CREBBP (0.41) | HSD11B1CYP2C9CYP3A4CYP2C19CREBBP | |
| SCHEMBL18380909 | 0.83 | HSD11B1 (0.37) | HSD11B1CYP2C9CYP3A4CYP2C19DPP4 | |
| SCHEMBL17120320 | 0.81 | ALOX5 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |