Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17120312 | 1.00 | HSD11B1 (0.44) | HSD11B1CYP2C9CYP2C19CYP3A4EP300 | |
| SCHEMBL15241496 | 0.91 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4EP300 | |
| SCHEMBL15241456 | 0.90 | HSD11B1 (0.47) | HSD11B1CYP2C9CYP2C19CYP3A4EP300 | |
| SCHEMBL15436370 | 0.89 | HSD11B1 (0.46) | HSD11B1CYP2C9CYP2C19CYP3A4EP300 | |
| SCHEMBL15436374 | 0.89 | CYP2C19 (0.46) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15436348 | 0.87 | HSD11B1 (0.43) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15241450 | 0.86 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL17120455 | 0.86 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4EP300 | |
| SCHEMBL15436303 | 0.84 | CREBBP (0.36) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL14865120 | 0.82 | HSD11B1 (0.43) | HSD11B1CYP2C9CYP2C19CYP3A4ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424865-B1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2017-01-18 | — | — | EP | disclosed |
| EP-2687525-B1 | CYCLIC INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2015-09-23 | — | — | EP | disclosed |
| WO-2009134400-A1 | CYCLIC INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-11-05 | — | — | WO | disclosed |