Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 11/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | USP19 | O94966 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624909 | 0.89 | HSD11B1 (0.44) | CYP2C19HSD11B1CYP2C9CYP3A4 | |
| SCHEMBL17120312 | 0.89 | HSD11B1 (0.44) | CYP2C19HSD11B1CYP2C9CYP3A4 | |
| SCHEMBL15241517 | 0.84 | HSD11B1 (0.47) | CYP2C19HSD11B1CYP2C9CYP3A4 | |
| SCHEMBL15241450 | 0.83 | HSD11B1 (0.45) | CYP2C19HSD11B1CYP2C9CYP3A4TRPM8 | |
| SCHEMBL15436348 | 0.81 | HSD11B1 (0.43) | CYP2C19HSD11B1CYP2C9CYP3A4 | |
| SCHEMBL15241496 | 0.81 | HSD11B1 (0.45) | CYP2C19HSD11B1CYP2C9CYP3A4PTGS2 | |
| SCHEMBL14865120 | 0.80 | HSD11B1 (0.43) | CYP2C19HSD11B1CYP2C9CYP3A4PTGS2 | |
| SCHEMBL17120364 | 0.80 | HSD11B1 (0.46) | CYP2C19HSD11B1CYP2C9CYP3A4TRPM8 | |
| SCHEMBL17120441 | 0.80 | HSD11B1 (0.46) | CYP2C19HSD11B1CYP2C9CYP3A4 | |
| SCHEMBL15241456 | 0.79 | HSD11B1 (0.47) | CYP2C19HSD11B1CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687525-A1 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 | Boehringer Ingelheim International GmbH (DE) | 2014-01-22 | — | — | EP | disclosed |