Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.72 |
| ▸ | PGR | P06401 | 11/20 | 0.72 |
| ▸ | AR | P10275 | 8/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | ESR1 | P03372 | 3/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aglepristone SCHEMBL2108967 | 1.00 | NR3C1 (0.72) | NR3C1PGRARCYP3A4CYP2D6 | |
| Aglepristone SCHEMBL16673291 | 1.00 | NR3C1 (0.72) | NR3C1PGRARCYP3A4CYP2D6 | |
| Aglepristone SCHEMBL9849187 | 1.00 | NR3C1 (0.72) | NR3C1PGRARCYP3A4CYP2D6 | |
| SCHEMBL9359259 | 0.94 | NR3C1 (0.71) | NR3C1PGRARCYP3A4CYP2D6 | |
| SCHEMBL9847474 | 0.94 | NR3C1 (0.71) | NR3C1PGRARCYP3A4CYP2D6 | |
| SCHEMBL20621627 | 0.92 | NR3C1 (0.73) | NR3C1PGRARCYP3A4CYP2D6 | |
| Lilopristone SCHEMBL21740506 | 0.92 | PGR (0.71) | NR3C1PGRARCYP3A4CYP2D6 | |
| Lilopristone SCHEMBL21010775 | 0.92 | PGR (0.71) | NR3C1PGRARCYP3A4CYP2D6 | |
| Lilopristone SCHEMBL21740509 | 0.92 | PGR (0.71) | NR3C1PGRARCYP3A4CYP2D6 | |
| Lilopristone SCHEMBL10453406 | 0.92 | PGR (0.71) | NR3C1PGRARCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009134725-A2 | COMPOSITIONS AND METHODS FOR TREATING PROGESTERONE-DEPENDENT CONDITIONS | REPROS THERAPEUTICS INC. (US) | 2009-11-05 | — | — | WO | disclosed |