Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 17/20 | 0.42 |
| ▸ | SRC | P12931 | 13/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625358 | 0.86 | PIN1 (0.51) | ABL1SRCHRH4 | |
| SCHEMBL17324213 | 0.83 | ABL1 (0.56) | ABL1SRC | |
| SCHEMBL13625359 | 0.83 | ABL1 (0.40) | ABL1SRCHRH4 | |
| SCHEMBL1772735 | 0.81 | ABL1 (0.40) | ABL1SRCHRH4 | |
| SCHEMBL15859989 | 0.80 | MGAM (0.42) | ABL1SRCHRH4 | |
| SCHEMBL5218804 | 0.80 | KDM4E (0.57) | ABL1SRC | |
| SCHEMBL15860112 | 0.79 | ABL1 (0.41) | ABL1SRCHRH4 | |
| SCHEMBL15223892 | 0.79 | ABL1 (0.45) | ABL1SRC | |
| SCHEMBL15847133 | 0.78 | ABL1 (0.38) | ABL1SRCHRH4 | |
| SCHEMBL1773116 | 0.76 | CYP1A2 (0.42) | ABL1SRCHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622466-B2 | Azaindole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-11-24 | — | — | US | disclosed |
| US-20090005379-A1 | Azaindole-2-Carboxamide Derivatives | HOFFMANN-LA ROCHE, INC. | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005379-A1 | Azaindole-2-Carboxamide Derivatives | HRH3, HRH4, H1-5 | ABL1 524/4885SRC 2937/4885HRH4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.