Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 17/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 17/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.60 |
| ▸ | REN | P00797 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31258379 | 0.81 | REN (0.58) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL24872977 | 0.80 | REN (0.57) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL13131429 | 0.80 | REN (0.64) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL13625505 | 0.77 | REN (0.59) | KCNH2RENCYP3A4 | |
| SCHEMBL13625506 | 0.77 | REN (0.56) | SLC6A2SLC6A4KCNH2RENCYP3A4 | |
| SCHEMBL13625586 | 0.77 | REN (0.62) | KCNH2RENCYP3A4 | |
| SCHEMBL13625497 | 0.76 | REN (0.48) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL31258411 | 0.74 | REN (0.51) | SLC6A2SLC6A4KCNH2SLC6A3REN | |
| SCHEMBL1911550 | 0.74 | REN (1.00) | KCNH2REN | |
| SCHEMBL13625584 | 0.74 | REN (0.56) | SLC6A2SLC6A4KCNH2SLC6A3REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |