Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625581 | 0.80 | REN (0.47) | RENTP53SMN1; SMN2 | |
| SCHEMBL13131785 | 0.80 | REN (0.85) | REN | |
| SCHEMBL13625485 | 0.80 | REN (0.49) | RENTP53SMN1; SMN2 | |
| SCHEMBL1518536 | 0.79 | REN (0.78) | REN | |
| SCHEMBL1518538 | 0.79 | REN (0.78) | REN | |
| SCHEMBL13625851 | 0.79 | REN (0.78) | REN | |
| SCHEMBL1518534 | 0.79 | REN (0.78) | REN | |
| SCHEMBL12764105 | 0.79 | REN (0.78) | REN | |
| SCHEMBL13625497 | 0.78 | REN (0.48) | REN | |
| SCHEMBL13625588 | 0.78 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |