Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 17/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625580 | 0.90 | LMNA (0.52) | RENKCNH2 | |
| SCHEMBL13625498 | 0.89 | REN (0.68) | RENKCNH2 | |
| SCHEMBL13131700 | 0.85 | REN (0.67) | RENKCNH2 | |
| SCHEMBL13625583 | 0.81 | REN (0.56) | RENKCNH2 | |
| SCHEMBL13625485 | 0.80 | REN (0.49) | REN | |
| SCHEMBL12764127 | 0.79 | REN (0.83) | RENKCNH2 | |
| SCHEMBL12837206 | 0.79 | REN (0.83) | RENKCNH2 | |
| SCHEMBL1518525 | 0.79 | REN (0.83) | RENKCNH2 | |
| SCHEMBL1518523 | 0.79 | REN (0.83) | RENKCNH2 | |
| SCHEMBL1518522 | 0.79 | REN (0.83) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |