Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625505 | 0.85 | REN (0.59) | RENKCNH2CYP3A4 | |
| SCHEMBL13625586 | 0.84 | REN (0.62) | RENKCNH2CYP3A4 | |
| SCHEMBL13625504 | 0.79 | REN (0.64) | RENKCNH2CYP3A4 | |
| SCHEMBL13625497 | 0.78 | REN (0.48) | RENKCNH2CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL12837185 | 0.78 | REN (0.79) | RENKCNH2CYP3A4 | |
| SCHEMBL1518210 | 0.78 | REN (0.79) | RENKCNH2CYP3A4 | |
| SCHEMBL1518212 | 0.78 | REN (0.79) | RENKCNH2CYP3A4 | |
| SCHEMBL12764077 | 0.78 | REN (0.79) | RENKCNH2CYP3A4 | |
| SCHEMBL1518206 | 0.78 | REN (0.79) | RENKCNH2CYP3A4 | |
| SCHEMBL13625565 | 0.73 | REN (0.64) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |