Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13625586 | 0.86 | REN (0.62) | RENKCNH2CYP3A4 | |
| SCHEMBL13625505 | 0.83 | REN (0.59) | RENKCNH2CYP3A4 | |
| SCHEMBL13625503 | 0.79 | REN (0.52) | RENKCNH2CYP3A4 | |
| SCHEMBL8238386 | 0.79 | REN (0.68) | RENKCNH2 | |
| SCHEMBL1518482 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL1518483 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL1518481 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL13625849 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL12764056 | 0.79 | REN (1.00) | RENKCNH2CYP3A4 | |
| SCHEMBL13625565 | 0.78 | REN (0.64) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |