Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12520531 | 0.88 | TYR (0.56) | HMGCRLMNAMAPTXBP1HIF1A | |
| SCHEMBL1270868 | 0.86 | ALOX5 (0.56) | HMGCRLMNAMAPTALOX5TYR | |
| SCHEMBL13563249 | 0.85 | TYR (0.52) | HMGCRLMNAMAPTXBP1HIF1A | |
| SCHEMBL15177138 | 0.85 | ALOX5 (0.59) | LMNAMAPTALOX5TYR | |
| SCHEMBL5208612 | 0.85 | ALOX5 (0.57) | HMGCRLMNAMAPTXBP1HIF1A | |
| SCHEMBL364672 | 0.83 | ESR1 (0.53) | LMNAMAPTESR1ESR2CA3 | |
| SCHEMBL2410166 | 0.81 | PPARG (0.48) | HMGCRLMNAMAPTXBP1HIF1A | |
| Formaldehyde SCHEMBL27493223 | 0.80 | MAPT (0.49) | HMGCRLMNAMAPTXBP1HIF1A | |
| SCHEMBL21455683 | 0.80 | HMGCR (0.40) | HMGCRLMNAMAPTXBP1HIF1A | |
| SCHEMBL24648555 | 0.79 | LMNA (0.52) | LMNAMAPTXBP1HIF1AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3974419-A2 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | Zhejiang Ausun Pharmaceutical Co., Ltd. (CN) | 2022-03-30 | — | — | EP | disclosed |
| US-8486943-B2 | Tetrahydrocyclopenta[b]indole androgen receptor modulators | ELI LILLY AND COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| WO-2009140448-A1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |