Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 6/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058650 | 0.86 | HCAR3 (0.43) | EIF4A3ALOX15NFKB1BLMSMN1; SMN2 | |
| SCHEMBL2405536 | 0.77 | EIF4A3 (0.50) | EIF4A3ALOX15NFKB1BLMSMN1; SMN2 | |
| SCHEMBL3280762 | 0.76 | EIF4A3 (0.44) | EIF4A3ALOX15NFKB1BLMSMN1; SMN2 | |
| SCHEMBL23327339 | 0.68 | HPGD (0.43) | SMN1; SMN2ALDH1A1GPR35CYP2C19PIN1 | |
| SCHEMBL6899150 | 0.66 | PTPN1 (0.41) | ALOX15NFKB1BLMSMN1; SMN2HCAR3 | |
| SCHEMBL23428879 | 0.65 | ALOX15 (0.43) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL3281469 | 0.64 | GRIN1 (0.43) | EIF4A3ALOX15NFKB1BLMSMN1; SMN2 | |
| SCHEMBL3281466 | 0.64 | ALOX15 (0.42) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL1244073 | 0.63 | DAO (0.65) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL14208058 | 0.63 | DAO (0.58) | EIF4A3ALDH1A1LMNAGPR35CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |