Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626128 | 0.90 | BTK (0.41) | BTKEGFR | |
| SCHEMBL13626122 | 0.89 | BTK (0.55) | BTK | |
| SCHEMBL13626829 | 0.89 | BTK (0.55) | BTK | |
| SCHEMBL13626374 | 0.84 | BTK (0.41) | BTK | |
| SCHEMBL13626140 | 0.83 | BTK (0.39) | BTK | |
| SCHEMBL13626472 | 0.83 | BTK (0.55) | BTK | |
| SCHEMBL1422629 | 0.81 | BTK (0.44) | BTKBRD4 | |
| SCHEMBL13626828 | 0.80 | BTK (0.43) | BTKEGFRBRD4 | |
| SCHEMBL13626133 | 0.80 | BTK (0.57) | BTK | |
| SCHEMBL13626485 | 0.78 | SYK (0.47) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |