Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | CD63 | P08962 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626185 | 0.85 | JAK2 (0.53) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL1422423 | 0.82 | SYK (0.46) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL13626131 | 0.78 | BTK (0.43) | BTK | |
| SCHEMBL13626133 | 0.77 | BTK (0.57) | BTK | |
| SCHEMBL13626128 | 0.76 | BTK (0.41) | BTK | |
| SCHEMBL13626122 | 0.76 | BTK (0.55) | BTK | |
| SCHEMBL13626829 | 0.75 | BTK (0.55) | BTK | |
| SCHEMBL13626132 | 0.75 | BTK (0.50) | BTK | |
| SCHEMBL13626828 | 0.75 | BTK (0.43) | BTKNTRK1 | |
| SCHEMBL13626831 | 0.73 | BTK (0.51) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |