Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | MST1R | Q04912 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626829 | 0.89 | BTK (0.55) | BTK | |
| SCHEMBL13626122 | 0.83 | BTK (0.55) | BTK | |
| SCHEMBL12651425 | 0.82 | BTK (0.44) | BTKFGRSRCTECBMX | |
| SCHEMBL13626373 | 0.80 | BTK (0.41) | BTKFGRSRCTECBMX | |
| SCHEMBL13626131 | 0.80 | BTK (0.43) | BTKEGFRBRD4 | |
| SCHEMBL13626472 | 0.77 | BTK (0.55) | BTK | |
| SCHEMBL13626128 | 0.77 | BTK (0.41) | BTKEGFR | |
| SCHEMBL13626485 | 0.75 | SYK (0.47) | BTKNTRK1 | |
| SCHEMBL13626375 | 0.74 | BTK (0.52) | BTK | |
| SCHEMBL13626142 | 0.74 | BTK (0.54) | BTKFGRTECBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137596-A1 | SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |