Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.64 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439622 | 0.87 | HDAC8 (0.64) | CDK8MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL13626336 | 0.85 | KMO (0.61) | CDK8ROCK2SIRT2CTSB | |
| SCHEMBL13702281 | 0.84 | CDK8 (0.60) | AURKACDK8MAPK1KDM4EALDH1A1 | |
| SCHEMBL13702385 | 0.83 | MEN1 (0.61) | CDK8MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL13702254 | 0.83 | NR1H4 (0.60) | CDK8MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL1850444 | 0.81 | AURKA (0.47) | AURKACDK8ROCK2ROCK1CYP3A4 | |
| SCHEMBL13702348 | 0.81 | CDK8 (0.56) | CDK8MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL13702256 | 0.81 | CDK8 (0.56) | CDK8MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL3238803 | 0.81 | SIRT2 (0.58) | AURKAROCK2CYP3A4SMN1; SMN2SIRT2 | |
| SCHEMBL13702395 | 0.81 | AOC3 (0.54) | CDK8ROCK2CYP3A4MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291998-A1 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | EISAI R&D MANAGEMENT CO., LTD. | 2009-11-26 | — | — | US | disclosed |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291998-A1 | EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF | PSMC4, PSMB6, EPOR | AURKA 1273/4885CDK8 1408/4885ROCK2 2329/4885 |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | AURKA 4497/4885CDK8 960/4885ROCK2 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.