Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CCR1 | P32246 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001960 | 0.70 | ADRA2A (0.37) | KDM4EMAPTHSP90AA1LMNATP53 | |
| SCHEMBL29385656 | 0.69 | HSP90AA1 (0.39) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL29353635 | 0.69 | HSP90AA1 (0.39) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL352077 | 0.69 | HSP90AA1 (0.39) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL30358616 | 0.69 | HSP90AA1 (0.39) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL29360166 | 0.69 | HSP90AA1 (0.39) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL12599432 | 0.67 | LMNA (0.53) | KDM4EMAPTHSP90AA1LMNAMMP2 | |
| SCHEMBL15478965 | 0.67 | HTT (0.61) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL18567995 | 0.65 | HSP90AA1 (0.41) | KDM4EMAPTCCR1CCR5CCR8 | |
| SCHEMBL16533061 | 0.65 | MAPT (0.36) | KDM4EMAPTHIF1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |