Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626549 | 0.85 | NAMPT (0.51) | F10NAMPTRAB9ANPC1LMNA | |
| SCHEMBL13626504 | 0.85 | NAMPT (0.51) | F10NAMPTRAB9ANPC1LMNA | |
| SCHEMBL13626550 | 0.85 | NAMPT (0.51) | F10NAMPTRAB9ANPC1LMNA | |
| SCHEMBL14507138 | 0.81 | F10 (0.54) | F10NAMPTRAB9ANPC1LMNA | |
| SCHEMBL4605212 | 0.79 | F10 (0.54) | F10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4606642 | 0.79 | F10 (0.54) | F10TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13626540 | 0.78 | F10 (0.47) | F10NAMPTRAB9ANPC1ABCB1 | |
| SCHEMBL13626555 | 0.78 | F10 (0.49) | F10NAMPTRAB9AKDM4ELMNA | |
| SCHEMBL13626542 | 0.77 | F10 (0.43) | F10NAMPTMEN1KMT2AGAA | |
| SCHEMBL5544306 | 0.77 | TRPV1 (0.62) | NAMPTKDM4ELMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |