Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | CFTR | P13569 | 5/20 | 0.49 |
| ▸ | F10 | P00742 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626549 | 1.00 | NAMPT (0.51) | NAMPTCFTRF10HTR1AHTR7 | |
| SCHEMBL13626504 | 1.00 | NAMPT (0.51) | NAMPTCFTRF10HTR1AHTR7 | |
| SCHEMBL13626555 | 0.90 | F10 (0.49) | NAMPTCFTRF10HTR1ALMNA | |
| SCHEMBL13626551 | 0.89 | F10 (0.55) | NAMPTCFTRF10 | |
| SCHEMBL13626569 | 0.88 | LMNA (0.43) | NAMPTCFTRF10LMNAPKM | |
| SCHEMBL13626564 | 0.87 | F10 (0.54) | CFTRF10LMNAPKMMEN1 | |
| SCHEMBL13626540 | 0.87 | F10 (0.47) | NAMPTF10HTR1ALMNANPC1 | |
| SCHEMBL13664671 | 0.87 | F10 (0.54) | CFTRF10LMNAPKMMEN1 | |
| SCHEMBL13626545 | 0.85 | F10 (0.49) | NAMPTF10HTR1ALMNANPC1 | |
| SCHEMBL13626560 | 0.85 | F10 (0.52) | CFTRF10LMNAPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |