Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626549 | 0.90 | NAMPT (0.51) | F10HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL13626550 | 0.90 | NAMPT (0.51) | F10HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL13626504 | 0.90 | NAMPT (0.51) | F10HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL13626540 | 0.85 | F10 (0.47) | F10CA12CA2CA9HTR1A | |
| SCHEMBL13626551 | 0.82 | F10 (0.55) | F10NAMPTCFTR | |
| SCHEMBL13626569 | 0.79 | LMNA (0.43) | F10RAB9ANAMPTKDM4ELMNA | |
| SCHEMBL13626556 | 0.79 | F10 (0.55) | F10CFTR | |
| SCHEMBL13626536 | 0.78 | F10 (0.42) | F10LMNACFTR | |
| SCHEMBL13664671 | 0.78 | F10 (0.54) | F10LMNACFTR | |
| SCHEMBL13626564 | 0.78 | F10 (0.54) | F10LMNACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612089-B2 | Tetrahydroisoquinolines as factor Xa inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-03 | — | — | US | disclosed |