Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895333 | 0.88 | BRD4 (0.45) | KDRRAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL1897321 | 0.83 | MAPT (0.48) | KDRSMN1; SMN2MAPTMEN1GAA | |
| SCHEMBL1890715 | 0.81 | FLT3 (0.58) | KDRMAPTMEN1KMT2A | |
| SCHEMBL13548326 | 0.74 | BRAF (0.41) | RAB9AKDM4EALDH1A1HPGDGABRP | |
| SCHEMBL2199156 | 0.74 | KDM4E (0.43) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL2199469 | 0.73 | ALOX15 (0.46) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL3005183 | 0.73 | KDM4E (0.42) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL3608888 | 0.72 | BRD4 (0.47) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL14609650 | 0.71 | CSF1R (0.49) | TRPA1 | |
| SCHEMBL12999346 | 0.69 | TRPA1 (0.68) | KDRJAK3TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612092-B2 | Urea derivatives containing aromatic or heteroaromatic rings; 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide; prophylactic or therapeutic agent for a disease for which angiogenesis inhibition is effective | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |