Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.41 |
| ▸ | HTR2A | P28223 | 8/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248280 | 1.00 | HTR2C (0.41) | HTR2CHTR2AERN1CHRNB2CHRNB4 | |
| SCHEMBL4248733 | 0.81 | HTR2C (0.37) | HTR2CHTR2AHTR2B | |
| SCHEMBL4478534 | 0.81 | HTR2C (0.37) | HTR2CHTR2AHTR2B | |
| SCHEMBL13627323 | 0.81 | HTR2C (0.37) | HTR2CHTR2AHTR2B | |
| SCHEMBL13627312 | 0.79 | HTR2C (0.38) | HTR2C | |
| SCHEMBL4250357 | 0.79 | HTR2C (0.38) | HTR2C | |
| SCHEMBL13627308 | 0.77 | HTR2C (0.40) | HTR2CHTR2AHTR2BRECQLSLC6A4 | |
| SCHEMBL4244437 | 0.77 | HTR2C (0.40) | HTR2CHTR2AHTR2BRECQLSLC6A4 | |
| SCHEMBL4477657 | 0.77 | HTR2C (0.40) | HTR2CHTR2AHTR2BRECQLSLC6A4 | |
| SCHEMBL4481794 | 0.75 | ERN1 (0.40) | ERN1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |