Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | GRK3 | P35626 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473034 | 1.00 | GAA (0.38) | GAAUTS2RP2RX7EPHX2ABL1 | |
| SCHEMBL5955674 | 1.00 | GAA (0.38) | GAAUTS2RP2RX7EPHX2ABL1 | |
| SCHEMBL13627345 | 0.88 | UTS2R (0.40) | GAAUTS2RP2RX7EPHX2ABL1 | |
| SCHEMBL4488827 | 0.88 | UTS2R (0.40) | GAAUTS2RP2RX7EPHX2ABL1 | |
| SCHEMBL4472375 | 0.85 | HTR2A (0.35) | GAAP2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL13627331 | 0.85 | HTR2A (0.35) | GAAP2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL4472041 | 0.85 | HTR2A (0.35) | GAAP2RX7HTR2AHTR2CHTR2B | |
| SCHEMBL13627337 | 0.83 | CHRNB2 (0.40) | GAAHTR2AHTR2C | |
| SCHEMBL4492625 | 0.83 | CHRNB2 (0.40) | GAAHTR2AHTR2C | |
| SCHEMBL3130191 | 0.80 | GAA (0.41) | GAAUTS2REPHX2CYP2C9C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |