Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488827 | 1.00 | UTS2R (0.40) | UTS2REPHX2CYP2D6TSHRCYP2C19 | |
| SCHEMBL13627340 | 0.88 | GAA (0.38) | UTS2REPHX2CYP3A4CYP2C9ABL1 | |
| SCHEMBL5955674 | 0.88 | GAA (0.38) | UTS2REPHX2CYP3A4CYP2C9ABL1 | |
| SCHEMBL4473034 | 0.88 | GAA (0.38) | UTS2REPHX2CYP3A4CYP2C9ABL1 | |
| SCHEMBL13627343 | 0.86 | EGFR (0.36) | CYP2C19CYP1A2CYP3A4GAAP2RX7 | |
| SCHEMBL4473434 | 0.86 | EGFR (0.36) | CYP2C19CYP1A2CYP3A4GAAP2RX7 | |
| SCHEMBL13627347 | 0.80 | P2RX7 (0.38) | UTS2REPHX2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4480936 | 0.80 | P2RX7 (0.38) | UTS2REPHX2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4477909 | 0.80 | P2RX7 (0.38) | UTS2REPHX2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL3130191 | 0.78 | GAA (0.41) | UTS2REPHX2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618980-B2 | Pyrrolo(oxo)quinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-11-17 | — | — | US | disclosed |