Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914121 | 0.89 | RPA1 (0.45) | MGLLMALT1RPA1 | |
| SCHEMBL2917841 | 0.84 | MALT1 (0.44) | NTRK1MGLLHCRTR1HCRTR2MALT1 | |
| SCHEMBL2920770 | 0.82 | MALT1 (0.54) | NTRK1MGLLMALT1 | |
| SCHEMBL5268929 | 0.80 | MGLL (0.38) | NTRK1MGLLHCRTR1HCRTR2PIK3CD | |
| SCHEMBL2921813 | 0.80 | NTRK1 (0.51) | NTRK1MGLLPIK3CDPIK3CAMALT1 | |
| SCHEMBL2916328 | 0.79 | BRD4 (0.41) | NTRK1MGLLHCRTR1HCRTR2PIK3CD | |
| SCHEMBL2919121 | 0.79 | HCRTR1 (0.40) | NTRK1MGLLHCRTR1HCRTR2PIK3CD | |
| SCHEMBL2918250 | 0.79 | RPA1 (0.52) | NTRK1RPA1 | |
| SCHEMBL13637539 | 0.79 | MALT1 (0.45) | MGLLPIK3CDPIK3CAMALT1PIK3R2 | |
| SCHEMBL5531773 | 0.79 | OXTR (0.39) | NTRK1MALT1SLC16A3SLC16A1RPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622471-B2 | Pyrazole derivatives having a pyridazine and pyridine functionality | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2009-11-24 | — | — | US | disclosed |