Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.67 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627491 | 0.90 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1DRD4DRD3DRD2 | |
| SCHEMBL4494977 | 0.86 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1DRD3DRD2 | |
| SCHEMBL13627499 | 0.84 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1DRD3DRD2 | |
| SCHEMBL13627478 | 0.83 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627468 | 0.82 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627517 | 0.82 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627483 | 0.82 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1SIGMAR1 | |
| SCHEMBL13627466 | 0.81 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1DRD3DRD2 | |
| SCHEMBL13627469 | 0.81 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1DRD4DRD3DRD2 | |
| SCHEMBL13627498 | 0.81 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |