Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPY2R | P49146 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627481 | 0.80 | HSP90AA1 (0.48) | ALDH1A1KMT2ANPY2RHSP90AA1HSP90AB1 | |
| SCHEMBL4481238 | 0.80 | SMARCA2 (0.48) | ALDH1A1KMT2AHSP90AA1HSP90AB1LMNA | |
| SCHEMBL13627519 | 0.77 | HSP90AA1 (0.51) | ALDH1A1HSP90AA1HSP90AB1MAPT | |
| SCHEMBL13627512 | 0.76 | SMN1; SMN2 (0.52) | ALDH1A1KMT2ACYP2C9HSP90AA1HSP90AB1 | |
| SCHEMBL13627482 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSP90AA1HSP90AB1LMNA | |
| SCHEMBL13627468 | 0.76 | HSP90AA1 (0.63) | KMT2ACYP2C19HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL13627503 | 0.75 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627517 | 0.75 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 | |
| SCHEMBL4474252 | 0.75 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627505 | 0.74 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |