Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.47 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627491 | 0.84 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1DRD4DRD2DRD3 | |
| SCHEMBL13627488 | 0.83 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1COMTDRD4DRD2 | |
| SCHEMBL13627486 | 0.82 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1DRD4DRD2DRD3 | |
| SCHEMBL13627473 | 0.82 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627483 | 0.80 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1KDM4EMAPT | |
| SCHEMBL13627500 | 0.80 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1DRD2ALDH1A1KDM4E | |
| SCHEMBL13627477 | 0.79 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1DRD2DRD3MAPT | |
| SCHEMBL13627468 | 0.78 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL4496226 | 0.78 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4494977 | 0.78 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |