Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13627491 | 0.86 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1ALDH1A1LMNADRD2 | |
| SCHEMBL13627483 | 0.82 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL13627469 | 0.81 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1KDM4EALDH1A1TACR3 | |
| SCHEMBL13627468 | 0.81 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1 | |
| SCHEMBL4496226 | 0.80 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1LMNASRPK1 | |
| SCHEMBL4494977 | 0.80 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1DRD2 | |
| SCHEMBL13627489 | 0.80 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1KDM4EALDH1A1DRD2 | |
| SCHEMBL13627504 | 0.80 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1DRD2 | |
| SCHEMBL13627484 | 0.79 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL13627494 | 0.79 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |
| US-7612201-B2 | Pyrazole compounds | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2009-11-03 | — | — | US | disclosed |