2-Arachidonoylglycerol

2-Arachidonoylglycerol

SCHEMBL136278

CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FAAH O00519 3/20 1.00
MAPT P10636 2/20 1.00
ALDH1A1 P00352 1/20 1.00
HPGD P15428 1/20 1.00
CNR1 P21554 1/20 1.00
CNR2 P34972 1/20 1.00
S1PR1 P21453 1/20 0.69
PRKCA P17252 2/20 0.68
PRKCE Q02156 1/20 0.68
PRKCQ Q04759 1/20 0.68
PRKCD Q05655 1/20 0.68
MAPK1 P28482 1/20 0.66
MGLL Q99685 1/20 0.62
GPR55 Q9Y2T6 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Arachidonoylglycerol SCHEMBL3685146 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
2-Arachidonoylglycerol SCHEMBL136277 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
2-Arachidonoylglycerol SCHEMBL18062264 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL29575039 0.98 FAAH (0.97) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL4248585 0.97 FAAH (0.94) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL23782661 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL145068 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL29582801 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL30863743 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL4572639 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4060 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636251-B1 Glycoside-containing aqueous formulations having a lipophilic active component Doane Technology Group LLC (US) 2026-05-26 US claimed
EP-4739302-A2 HYALURONIC ACID BASED DRUG DELIVERY SYSTEMS Cella Therapeutics, LLC (US) 2026-05-13 EP claimed
EP-4734961-A1 NEW METHOD OF PRODUCING AN AQUEOUS MESOPARTICLE COMPOSITION COMPRISING A LIPOPHILIC COMPOUND BIOGNTX R&D B.V. (NL) 2026-05-06 EP claimed
US-20260102502-A1 CANNABINOID DENDRIMER COMPOSITIONS FOR TARGETED DELIVERY UNIV JOHNS HOPKINS (US) 2026-04-16 US claimed
US-20260097051-A1 CANNABICHROMENE AS A THERAPEUTIC MODALITY FOR COVID-19 AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) 2026-04-09 US claimed
EP-4713314-A1 A BINDING SITE TO PREVENT ENDOCANNABINOID CELLULAR REUPTAKE Universität Bern (CH) 2026-03-25 EP claimed
US-20260049977-A1 CELL-BASED ASSAY FOR QUANTIFYING THE POTENCY AND EFFICACY OF CANNABINOIDS AND/OR TERPENOIDS, AND METHODS OF USE THEREOF CANNAMETRIX LLC (US) 2026-02-19 US claimed
EP-4695192-A2 ANALGESIC COMPOUNDS COMPRISING CHARGED PARTICLES AND METHOD OF MANUFACTURE THEREOF University of Connecticut (US) 2026-02-18 EP claimed
EP-4358962-B1 TREATMENT FOR AUTOIMMUNE DISEASES COMPRISING NALTREXONE OR A METABOLITE OR ANALOG THEREOF, A CANNABINOID AND A 5-HT RECEPTOR AGONIST LDN PHARMA LTD (GB) 2026-02-04 EP claimed
US-12478091-B2 Vaporizable alkaloid compositions and methods of use thereof Ready Mix Naturals, LLC (US) 2025-11-25 US claimed
WO-2006047417-A2 DETECTION OF CANNABINOID RECEPTOR BIOMARKERS AND USES THEREOF UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2006-05-04 WO claimed
WO-2005085873-A2 DETECTION OF PRETERM LABOUR UNIVERSITY OF LEICESTER (GB) 2005-09-15 WO claimed
EP-1572311-A2 ASSAY FOR DETERMINING THE ACTIVITY OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2005-09-14 EP claimed
US-6790365-B2 WATER-INSOLUBLE MATERIAL KANEKA CORPORATION (JP) 2004-09-14 US claimed
US-20040171613-A1 Therapeutic agent for non-immediate type allergic diseases JAPAN TOBACCO INC. 2004-09-02 US claimed
WO-2004037371-A2 ASSAY FOR DETERMINING THE ACTIVITY OF FATTY ACID AMIDE HYDROLASE JANSSEN PHARMACEUTICA N.V. (BE) 2004-05-06 WO claimed
US-20020062099-A1 Adsorbent, adsorbing and removing process and adsorber for endogenous cannabinoid KANEKA CORPORATION (JP) 2002-05-23 US claimed
US-20020045157-A1 Adsorbent, adsorbing and removing process and adsorber for endogenous cannabinoid KANEKA CORPORATION (JP) 2002-04-18 US claimed
EP-1192977-A1 Adsorbent, adsorbing and removing process and adsorber for endogenous cannabinoid Kaneka Corporation (JP) 2002-04-03 EP claimed
EP-1181977-A1 Adsorbent, adsorbing and removing process and adsorber for endogenous cannabinoid Kaneka Corporation (JP) 2002-02-27 EP claimed