2-Arachidonoylglycerol

2-Arachidonoylglycerol

SCHEMBL3685146

CCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCC(=O)OC(CO)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FAAH O00519 3/20 1.00
MAPT P10636 2/20 1.00
ALDH1A1 P00352 1/20 1.00
HPGD P15428 1/20 1.00
CNR1 P21554 1/20 1.00
CNR2 P34972 1/20 1.00
S1PR1 P21453 1/20 0.69
PRKCA P17252 2/20 0.68
PRKCE Q02156 1/20 0.68
PRKCQ Q04759 1/20 0.68
PRKCD Q05655 1/20 0.68
MAPK1 P28482 1/20 0.66
MGLL Q99685 1/20 0.62
GPR55 Q9Y2T6 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Arachidonoylglycerol SCHEMBL136278 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
2-Arachidonoylglycerol SCHEMBL136277 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
2-Arachidonoylglycerol SCHEMBL18062264 1.00 FAAH (1.00) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL29575039 0.98 FAAH (0.97) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL4248585 0.97 FAAH (0.94) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL23782661 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL145068 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL29582801 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL30863743 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1
SCHEMBL4572639 0.95 MAPT (0.91) FAAHMAPTALDH1A1HPGDCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7763607-B2 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2010-07-27 US claimed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-7763607-B2 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2010-07-27 US disclosed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators CNR2, CNR1, KCNN1 FAAH 109/4885MAPT 3562/4885ALDH1A1 3168/4885
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators CNR1, CNR2, KCNJ11 FAAH 162/4885MAPT 2849/4885ALDH1A1 2372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.