Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | MC3R | P41968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227483 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| SCHEMBL1933894 | 0.84 | POLB (0.50) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| SCHEMBL28519924 | 0.82 | POLB (0.49) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| SCHEMBL1265669 | 0.75 | POLB (0.42) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| Ampyzine SCHEMBL30627403 | 0.73 | — | — | |
| SCHEMBL13367380 | 0.73 | POLB (0.55) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| Ampyzine SCHEMBL160265 | 0.73 | — | — | |
| SCHEMBL19972911 | 0.73 | POLB (0.47) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| Ampyzine SCHEMBL122178 | 0.72 | POLB (0.50) | KDM4EALDH1A1CYP1A2POLBNAPRT | |
| SCHEMBL762423 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1POLBNAPRTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619092-B2 | Piperidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-11-17 | — | — | US | disclosed |
| US-7619092-B2 | Piperidine compounds | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-11-17 | — | — | US | disclosed |