Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 4/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855366 | 0.79 | TGM2 (0.72) | TGM2KDRPIM1CCNB2CDK1 | |
| SCHEMBL4855375 | 0.79 | TGM2 (0.72) | TGM2KDRPIM1CCNB2CDK1 | |
| SCHEMBL13910827 | 0.79 | TGM2 (0.48) | TGM2KDRPIM1CES1RPS6KA3 | |
| SCHEMBL19931150 | 0.79 | TGM2 (0.59) | TGM2KDRPIM1PIM3PIM2 | |
| SCHEMBL249650 | 0.78 | MEN1 (0.58) | KDRPIM1PLK4MEN1KMT2A | |
| SCHEMBL249651 | 0.78 | MEN1 (0.58) | KDRPIM1PLK4MEN1KMT2A | |
| SCHEMBL5773323 | 0.77 | RAF1 (0.73) | PIM1PIM3PIM2PLK4MEN1 | |
| SCHEMBL7980521 | 0.77 | RAF1 (0.73) | PIM1PIM3PIM2PLK4MEN1 | |
| SCHEMBL2573841 | 0.77 | PIM1 (0.57) | TGM2KDRPIM1MEN1KMT2A | |
| SCHEMBL2573839 | 0.77 | PIM1 (0.57) | TGM2KDRPIM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| US-7612065-B2 | Inhibitors of c-JUN N-terminal kinases (JNK) | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-03 | — | — | US | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | SALITURO FRANCESCO G | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033022-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) | MAP3K1, JUN, MAP3K7 | TGM2 2774/4885KDR 3535/4885PIM1 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.