Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954503 | 0.78 | PARP1 (0.44) | CDC7 | |
| SCHEMBL27311284 | 0.78 | PARP1 (0.44) | CDC7 | |
| SCHEMBL18330320 | 0.74 | PDE4A (0.52) | PDE4A | |
| SCHEMBL22490639 | 0.74 | HRH3 (0.37) | PDE4ACYP3A4 | |
| SCHEMBL30489158 | 0.74 | PDE4A (0.52) | PDE4A | |
| SCHEMBL18527085 | 0.70 | KDM4E (0.47) | RPS6KA5LMNAMAPT | |
| SCHEMBL1770250 | 0.70 | NOTUM (0.35) | RPS6KA5METDAOTSHRRAPGEF4 | |
| SCHEMBL569208 | 0.69 | HPGD (0.42) | RPS6KA5LMNA | |
| SCHEMBL1253057 | 0.69 | RXFP1 (0.35) | — | |
| SCHEMBL21292094 | 0.68 | PDE4A (0.49) | PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618979-B2 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |