Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311297 | 0.80 | KCNJ1 (0.54) | NOTUMALDH1A1HPGDTSHR | |
| SCHEMBL13629601 | 0.79 | NOTUM (0.58) | NOTUMKEAP1CYP19A1HCRTR1HCRTR2 | |
| SCHEMBL5193938 | 0.75 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL30412896 | 0.75 | NOTUM (0.66) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL6540845 | 0.74 | CYP11B1 (0.54) | NOTUMALDH1A1CYP19A1POLB | |
| SCHEMBL31402235 | 0.73 | ALDH1A1 (0.40) | NOTUMALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL7120569 | 0.71 | MAPT (0.50) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL4205532 | 0.70 | ATM (0.45) | NOTUMALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL8530040 | 0.70 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL31402350 | 0.70 | FGFR1 (0.40) | NOTUMALDH1A1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |