Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DBH | P09172 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15889924 | 0.81 | NOTUM (0.63) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL30413228 | 0.81 | NOTUM (0.63) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL30412896 | 0.79 | NOTUM (0.66) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL13629593 | 0.79 | NOTUM (0.52) | NOTUMKEAP1CYP19A1HCRTR1HCRTR2 | |
| SCHEMBL16911508 | 0.77 | NOTUM (0.46) | NOTUMHCRTR1HCRTR2KMT2A | |
| SCHEMBL16787394 | 0.77 | NOTUM (0.58) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL4564455 | 0.77 | NOTUM (0.58) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL16911330 | 0.75 | HTT (0.44) | KMT2ADBH | |
| SCHEMBL20437909 | 0.74 | NOTUM (0.58) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL28166936 | 0.74 | NOTUM (0.67) | NOTUMKEAP1CYP19A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |
| US-7622487-B2 | Piperidine derivative, process for producing the same, and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-24 | — | — | US | disclosed |